Apply These Secret WAYS TO Improve Pregnancy Loss And Chromosome Testing For Miscarriages

Although most couples are blissfully unacquainted with the statistics surrounding miscarriage, pregnancy loss is actually quite common, with 10-25% of recognized pregnancies ending in miscarriage. Assuming you have suffered a pregnancy loss or are currently in the process of having a miscarriage, you might be wondering what caused the loss and worry about whether it’ll happen again. This article aims to answer the next questions:

What causes miscarriage?
How common is pregnancy loss?
What sort of genetic testing is available for miscarriage tissue?
How can chromosome testing help?
Causes of Miscarriage

There are many different reasons why miscarriage occurs, but the most common cause for first trimester miscarriage is really a chromosome abnormality. Chromosome abnormalities – extra or missing whole chromosomes, also called “aneuploidy” – occur because of a mis-division of the chromosomes in the egg or sperm involved with a conception. Typically, humans have 46 chromosomes that come in 23 pairs (22 pairs numbered from 1 to 22 and then the sex chromosomes, X and Y). For a child to develop normally it is necessary that it have the right level of chromosome material; missing or extra material at the time of conception or within an embryo or fetus could cause a female to either not become pregnant, miscarry, or have a child with a chromosome syndrome such as Down syndrome.

Over 50% of most first trimester miscarriages are caused by chromosome abnormalities. This number may be closer to 75% or higher for women aged 35 years and over who have experienced recurrent pregnancy loss. Overall, the rate of chromosome abnormalities and the rate of miscarriage both increase with maternal age, with a steep upsurge in women older than 35.

Pregnancy Loss – How Common could it be?

Miscarriage is a lot more common than a lot of people think. Up to one atlanta divorce attorneys four recognized pregnancies is lost in first trimester miscarriage. The chance of experiencing a miscarriage also increases as a mother ages.

Most women who experience a miscarriage continue to get a healthy pregnancy and never miscarry again. However, some women seem to be more prone to miscarriage than others. About five percent of fertile couples will experience two or more miscarriages.

Of note, the rate of miscarriage appears to be increasing. One reason for this can be awareness – more women know they’re having a miscarriage because home pregnancy tests have improved early pregnancy detection rates over the past decade, whereas before the miscarriage would have appeared to be just a unique period. Another reason could be that more women are conceiving at older ages.

Types of Genetic Testing Ideal for Miscarriages

Genetic testing actually identifies many different types of testing that you can do on the DNA in a cell. For miscarriage tissue, also known as products of conception (POC), probably the most useful type of test to execute is a chromosome analysis. A chromosome analysis (also known as chromosome testing) can examine all 23 pairs of chromosomes for the current presence of extra or missing chromosome material (aneuploidy). Because so many miscarriages are due to aneuploidy, chromosome analysis on the miscarriage tissue can often identify the reason behind the pregnancy loss.

The most common approach to chromosome analysis is called karyotyping. Newer methods include advanced technologies such as for example microarrays.

Karyotyping analyzes all 23 pairs of chromosome but requires cells from the miscarriage tissue to first be grown in the laboratory, an activity called “cell culture”. For this reason requirement, tissue that is passed at home is frequently unable to be tested with this particular method. About 20% or more of miscarriage samples neglect to grow and thus no email address details are available. Additionally, karyotyping is unable to tell the difference between cells from mom (maternal cells) and cells from the fetus. In case a normal female result is found, it may be the right result for the fetus or it may be maternal cell contamination (MCC) in which the result actually comes from testing the mother’s cells present in the pregnancy tissue rather than the fetal cells. MCC appears to occur in about 30% or more of the samples tested by traditional karyotype. Results from karyotyping usually take a few weeks to months another from the laboratory.

Microarray testing is really a new type of genetic testing done on miscarriage samples; both most common forms of microarray testing are array CGH (comparative genomic hybridization) and chromosome SNP (single-nucleotide polymorphism) microarray. Microarray testing can be in a position to test all 23 pairs of chromosomes for aneuploidy, but does not require cell culture. Therefore, you’re more prone to receive results and the outcomes are usually returned faster when microarray testing is used. Additionally, some laboratories are collecting an example of the mother’s blood as well the miscarriage tissue is delivered to enable immediate detection of maternal cell contamination (MCC).

Chromosome Testing – How do it help?

infant loss In case a chromosome abnormality is identified, the sort of abnormality found could be assessed to help answer fully the question: “Will this eventually me again?”. Quite often, chromosome abnormalities in an embryo or fetus are not inherited and have a low chance to occur in future pregnancies. Sometimes, a specific chromosome finding in a miscarriage alerts your doctor to do further studies to research the chance of an underlying genetic or chromosome problem in your family that predisposes one to have miscarriages.

Furthermore, if a chromosome abnormality is identified it could prevent the need for other, sometimes quite costly, studies your doctor might consider to investigate the reason for the miscarriage.

Lastly, knowing the explanation for a pregnancy loss can help a couple of start the emotional healing up process, moving past the question of “Why did this happen to me?”.

Chromosome testing could be especially very important to patients with repeated miscarriages, as it can either give clues to an underlying chromosomal cause for the miscarriages or eliminate chromosome errors as the reason behind the miscarriages and invite their doctor to pursue other styles of testing. For couples with multiple miscarriages determined to have a chromosomal cause, in vitro fertilization (IVF) with preimplantation genetic diagnosis (PGD) testing may be able to help increase their chances of having a successful healthy pregnancy.

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