Apply These Secret WAYS TO Improve Pregnancy Loss And Chromosome Testing For Miscarriages

Although most couples are blissfully unacquainted with the statistics surrounding miscarriage, pregnancy loss is in fact quite common, with 10-25% of recognized pregnancies ending in miscarriage. Should you have suffered a pregnancy loss or are in the process of experiencing a miscarriage, you might be wondering what caused the loss and worry about whether it’ll happen again. This short article aims to answer the next questions:

What causes miscarriage?
How common is pregnancy loss?
What type of genetic testing can be acquired for miscarriage tissue?
How can chromosome testing help?
Causes of Miscarriage

There are many different reasons why miscarriage occurs, but the most common cause for first trimester miscarriage is really a chromosome abnormality. Chromosome abnormalities – extra or missing whole chromosomes, also known as “aneuploidy” – occur because of a mis-division of the chromosomes in the egg or sperm involved with a conception. Typically, humans have 46 chromosomes that come in 23 pairs (22 pairs numbered from 1 to 22 and then the sex chromosomes, X and Y). For a baby to develop normally it is necessary that it have the right level of chromosome material; missing or extra material during conception or within an embryo or fetus can cause a woman to either not become pregnant, miscarry, or have a baby with a chromosome syndrome such as for example Down syndrome.

Over 50% of all first trimester miscarriages are caused by chromosome abnormalities. This number may be closer to 75% or more for women aged 35 years and over who have experienced recurrent pregnancy loss. Overall, the rate of chromosome abnormalities and the rate of miscarriage both increase with maternal age, with a steep upsurge in women older than 35.

Pregnancy Loss – How Common is it?

Miscarriage is far more common than a lot of people think. Up to one atlanta divorce attorneys four recognized pregnancies is lost in first trimester miscarriage. The opportunity of experiencing a miscarriage also increases as a mother ages.

Nearly all women who experience a miscarriage continue to possess a healthy pregnancy and never miscarry again. However, some women seem to be more susceptible to miscarriage than others. About five percent of fertile couples will experience several miscarriages.

Of note, the rate of miscarriage seems to be increasing. One reason for this may be awareness – more women know they’re having a miscarriage because home pregnancy tests have improved early pregnancy detection rates in the last decade, whereas previously the miscarriage would have were just an unusual period. Another reason could be that more women are conceiving at older ages.

Types of Genetic Testing Helpful for Miscarriages

Genetic testing actually refers to many different types of testing that you can do on the DNA in a cell. For miscarriage tissue, also called products of conception (POC), the most useful type of test to perform is a chromosome analysis. A chromosome analysis (also called chromosome testing) can examine all 23 pairs of chromosomes for the current presence of extra or missing chromosome material (aneuploidy). Because so many miscarriages are caused by aneuploidy, chromosome analysis on the miscarriage tissue could identify the reason for the pregnancy loss.

The most common method of chromosome analysis is called karyotyping. Newer methods include advanced technologies such as microarrays.

Pregnancy Karyotyping analyzes all 23 pairs of chromosome but requires cells from the miscarriage tissue to first be grown in the laboratory, a process called “cell culture”. For this reason requirement, tissue that is passed at home is often unable to be tested with this method. About 20% or more of miscarriage samples fail to grow and thus no email address details are available. Additionally, karyotyping is unable to tell the difference between cells from the mother (maternal cells) and cells from the fetus. In case a normal female result is found, it may be the right result for the fetus or it could be maternal cell contamination (MCC) where the result actually comes from testing the mother’s cells within the pregnancy tissue rather than the fetal cells. MCC seems to occur in about 30% or even more of the samples tested by traditional karyotype. Results from karyotyping usually take a few weeks to months to come back from the laboratory.

Microarray testing is really a new kind of genetic testing done on miscarriage samples; both most common forms of microarray testing are array CGH (comparative genomic hybridization) and chromosome SNP (single-nucleotide polymorphism) microarray. Microarray testing can be in a position to test all 23 pairs of chromosomes for aneuploidy, but does not require cell culture. Therefore, you’re more likely to receive results and the outcomes are usually returned faster when microarray testing can be used. Additionally, some laboratories are collecting an example of the mother’s blood as well the miscarriage tissue is delivered to enable immediate detection of maternal cell contamination (MCC).

Chromosome Testing – How can it help?

If a chromosome abnormality is identified, the sort of abnormality found could be assessed to help answer the question: “Will this eventually me again?”. Quite often, chromosome abnormalities within an embryo or fetus aren’t inherited and have a minimal possiblity to occur in future pregnancies. Sometimes, a specific chromosome finding in a miscarriage alerts your doctor to do further studies to research the possibility of an underlying genetic or chromosome problem in your loved ones that predisposes you to have miscarriages.

Furthermore, in case a chromosome abnormality is identified it can prevent the need for other, sometimes quite costly, studies your doctor might consider to investigate the cause of the miscarriage.

Lastly, knowing the reason for a pregnancy loss can help a couple start the emotional healing process, moving at night question of “Why did this eventually me?”.

Chromosome testing could be especially important for patients with repeated miscarriages, as it can either give clues to an underlying chromosomal cause for the miscarriages or rule out chromosome errors as the reason for the miscarriages and allow their doctor to pursue other styles of testing. For couples with multiple miscarriages determined to truly have a chromosomal cause, in vitro fertilization (IVF) with preimplantation genetic diagnosis (PGD) testing might be able to help increase their chances of having a successful healthy pregnancy.

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