Apply These Secret Techniques To Improve Pregnancy Loss And Chromosome Testing For Miscarriages

Although most couples are blissfully unaware of the statistics surrounding miscarriage, pregnancy loss is really quite common, with 10-25% of recognized pregnancies ending in miscarriage. Assuming you have suffered a pregnancy loss or are currently in the process of having a miscarriage, you could be wondering what caused the loss and worry about whether it’ll happen again. This article aims to answer the next questions:

What causes miscarriage?
How common is pregnancy loss?
Which kind of genetic testing can be acquired for miscarriage tissue?
How do chromosome testing help?
Causes of Miscarriage

There are many different explanations why miscarriage occurs, but the most common cause for first trimester miscarriage is really a chromosome abnormality. Chromosome abnormalities – extra or missing whole chromosomes, also known as “aneuploidy” – occur due to a mis-division of the chromosomes in the egg or sperm involved with a conception. Typically, humans have 46 chromosomes that come in 23 pairs (22 pairs numbered from 1 to 22 and the sex chromosomes, X and Y). For a baby to develop normally it is necessary that it have exactly the right level of chromosome material; missing or extra material at the time of conception or within an embryo or fetus could cause a female to either not become pregnant, miscarry, or have a baby with a chromosome syndrome such as Down syndrome.

Over 50% of all first trimester miscarriages are caused by chromosome abnormalities. This number could be closer to 75% or higher for women aged 35 years and over who have experienced recurrent pregnancy loss. Overall, the rate of chromosome abnormalities and the rate of miscarriage both increase with maternal age, with a steep increase in women older than 35.

Pregnancy Loss – How Common is it?

Miscarriage is far more common than most people think. Up to one atlanta divorce attorneys four recognized pregnancies is lost in first trimester miscarriage. The chance of having a miscarriage also increases as a mother ages.

Most women who experience a miscarriage continue to have a healthy pregnancy and never miscarry again. However, some women appear to be more susceptible to miscarriage than others. About five percent of fertile couples will experience several miscarriages.

Of note, the rate of miscarriage appears to be increasing. One reason for this can be awareness – more women know they are having a miscarriage because home pregnancy tests have improved early pregnancy detection rates over the past decade, whereas during the past the miscarriage would have appeared to be just a unique period. Another reason could be that more women are conceiving at older ages.

Types of Genetic Testing Ideal for Miscarriages

Genetic testing actually identifies many different types of testing that you can do on the DNA in a cell. For miscarriage tissue, also known as products of conception (POC), the most useful type of test to perform is a chromosome analysis. A chromosome analysis (also called chromosome testing) can examine all 23 pairs of chromosomes for the presence of extra or missing chromosome material (aneuploidy). Because so many miscarriages are caused by aneuploidy, chromosome analysis on the miscarriage tissue could identify the reason behind the pregnancy loss.

The most common approach to chromosome analysis is named karyotyping. Newer methods include advanced technologies such as for example microarrays.

Karyotyping analyzes all 23 pairs of chromosome but requires cells from the miscarriage tissue to first be grown in the laboratory, an activity called “cell culture”. Due to this requirement, tissue that’s passed at home is frequently unable to be tested with this method. About 20% or more of miscarriage samples fail to grow and thus no email address details are available. Additionally, karyotyping struggles to tell the difference between cells from the mother (maternal cells) and cells from the fetus. In case a normal female result is available, it may be the right result for the fetus or it can be maternal cell contamination (MCC) where the result actually comes from testing the mother’s cells present in the pregnancy tissue rather than the fetal cells. MCC seems to occur in about 30% or more of the samples tested by traditional karyotype. Results from karyotyping usually have a few weeks to months another from the laboratory.

Microarray testing is a new kind of genetic testing done on miscarriage samples; both most common forms of microarray testing are array CGH (comparative genomic hybridization) and chromosome SNP (single-nucleotide polymorphism) microarray. Microarray testing is also in a position to test all 23 pairs of chromosomes for aneuploidy, but does not require cell culture. pregnancy loss Therefore, you are more prone to receive results and the outcomes are usually returned faster when microarray testing is used. Additionally, some laboratories are collecting an example of the mother’s blood concurrently the miscarriage tissue is sent to enable immediate detection of maternal cell contamination (MCC).

Chromosome Testing – How can it help?

If a chromosome abnormality is identified, the sort of abnormality found could be assessed to help answer the question: “Will this happen to me again?”. Quite often, chromosome abnormalities in an embryo or fetus are not inherited and have a minimal possiblity to occur in future pregnancies. Sometimes, a particular chromosome finding in a miscarriage alerts your physician to do further studies to research the chance of an underlying genetic or chromosome problem in your loved ones that predisposes you to have miscarriages.

Furthermore, in case a chromosome abnormality is identified it can prevent the need for other, sometimes quite costly, studies your doctor might consider to investigate the cause of the miscarriage.

Lastly, knowing the reason for a pregnancy loss might help a couple of start the emotional healing process, moving at night question of “Why did this eventually me?”.

Chromosome testing could be especially important for patients with repeated miscarriages, as it can either give clues to an underlying chromosomal cause for the miscarriages or rule out chromosome errors as the reason behind the miscarriages and invite their doctor to pursue other styles of testing. For couples with multiple miscarriages determined to truly have a chromosomal cause, in vitro fertilization (IVF) with preimplantation genetic diagnosis (PGD) testing might be able to help increase their likelihood of having a successful healthy pregnancy.

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